There is a vast amount of molecular information regarding the differentiation of T lymphocytes, in particular regarding in vitro experimental treatments that modify their differentiation process. This publicly available information was used to infer the regulatory network that controls the differentiation of T lymphocytes into CD4+ and CD8+ cells. Hereby we present a network that consists of 50 nodes and 97 regulatory interactions, representing the main signaling circuits established among molecules and molecular complexes regulating the differentiation of T cells. The network was converted into a continuous dynamical system in the form of a set of coupled ordinary differential equations, and its dynamical behavior was studied. With the aid of numerical methods, nine fixed point attractors were found for the dynamical system. These attractors correspond to the activation patterns observed experimentally for the following cell types: CD4?CD8?, CD4+CD8+, CD4+ naive, Th1, Th2, Th17, Treg, CD8+ naive, and CTL. Furthermore, the model is able to describe the differentiation process from the precursor CD4?CD8? to any of the effector types due to a specific series of extracellular signals. Helikar Tomas thelika@unmc.edu University of Nebraska - Lincoln 2013-08-27T19:12:07Z 2017-08-12T21:04:24Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z 2015-11-15T18:45:56Z

<font face="Georgia" size="2">T-box expressed in T cells</font><div><font face="Georgia" size="2">T-box 21 (TBX21)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/Q9UL17" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q9UL17</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/30009" ref="ordinalpos=2&ncbi_uid=30009&link_uid=30009" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">TBX21</span></a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">30009</span></font></div><div><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2">Eomesodermin homolog (Xenopus laevis) (EOMES)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P79944" style="text-decoration: none; background-color: rgb(255, 255, 255);">P79944</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/495078" ref="ordinalpos=12&ncbi_uid=495078&link_uid=495078" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">tbx21</span></a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">495078</span></font></div><div style="font-size: 10pt; font-family: Arial, Verdana;"><br/></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Signal transducer and activator of transcription 4 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q14765" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q14765</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/6775" ref="ordinalpos=1&ncbi_uid=6775&link_uid=6775" style="color: rgb(100, 42, 143); line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">STAT4</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 6775</font></span></div>

2015-11-15T18:45:56Z

<div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">GATA binding protein 3 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P23771" style="text-decoration: none; background-color: rgb(255, 255, 255);">P23771</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/2625" ref="ordinalpos=1&ncbi_uid=2625&link_uid=2625" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">GATA3</span></a></font></div><div><font face="Georgia" size="2"><font color="#000000" style="text-decoration: none; background-color: rgb(255, 255, 255);">NCBI Gene ID: </font><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">2625</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Eomesodermin [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/O95936" style="text-decoration: none; background-color: rgb(255, 255, 255);">O95936</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/8320" ref="ordinalpos=2&ncbi_uid=8320&link_uid=8320" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">EOMES</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 8320</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2" style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 2 receptor [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div style="font-style: normal; font-variant: normal; font-weight: normal;"><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px;"><br/></span></font></div><div style="font-style: normal; font-variant: normal; font-weight: normal;"><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px;">Composed of the following subunits:</span></font></div><div style="font-style: normal; font-variant: normal; font-weight: normal;"><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px;"><br/></span></font><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P01589" style="text-decoration: none; background-color: rgb(255, 255, 255);">P01589</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3559" ref="ordinalpos=2&ncbi_uid=3559&link_uid=3559" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL2RA</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3559</font></span></div></div><div style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"><br/></font></span></div><div><div><font face="Georgia" size="2" style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">UniProt ID: </span></font><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px;">P14784</span></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Gene Name: I</span>L2RB</font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div><div><div><font face="Georgia" size="2" style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">UniProt ID: </span></font><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px;">P31785</span></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Gene Name: I</span>L2RG</font></div></div></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">SMAD family member 2 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q15796" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q15796</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4087" ref="ordinalpos=1&ncbi_uid=4087&link_uid=4087" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">SMAD2</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 4087</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 27 </span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">receptor</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">, alpha [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q6UWB1" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q6UWB1</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/9466" ref="ordinalpos=6&ncbi_uid=9466&link_uid=9466" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL27RA</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 9466</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Transforming growth factor, beta receptor 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P36897" style="text-decoration: none; background-color: rgb(255, 255, 255);">P36897</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/7046" ref="ordinalpos=6&ncbi_uid=7046&link_uid=7046" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">TGFBR1</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 7046</font></span></div><div><br/></div><div><font face="Georgia"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Transforming growth factor, beta receptor 2 [</span><em style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">UniProt ID: </span></font><a href="http://www.uniprot.org/uniprot/P37173" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P37173</a></div><div><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/7046" ref="ordinalpos=6&ncbi_uid=7046&link_uid=7046" style="line-height: 17.9998016357422px; white-space: nowrap; background-color: rgb(255, 255, 255);">TGFBR</a>2</font></div><div><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 7048</font></span></div></div><div><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"><br/></font></span></div><div><font face="Georgia"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Transforming growth factor, beta receptor 3 [</span><em style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">UniProt ID: </span></font><a href="http://www.uniprot.org/uniprot/Q03167" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q03167</a></div><div><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">Gene Name: TGFBR3</span></font></div><div><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: </font></span><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 12px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">7049</span></div></div><div><br/></div>

2015-11-15T18:45:56Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Signal transducer and activator of transcription 1</font></span><div><font face="Georgia" size="2"><span style="line-height: 15.989583969116211px;">Uniport ID: </span><a href="http://www.uniprot.org/uniprot/P42224">P42224</a><span style="line-height: 15.989583969116211px;"><br/></span></font><div><div style="line-height: normal;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene Name: STAT1 </font></span></div></div></div><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">6772</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Signal transducer and activator of transcription 6, interleukin-4 induced [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P42226" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42226</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/6778" ref="ordinalpos=2&ncbi_uid=6778&link_uid=6778" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">STAT6</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 6778</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Forkhead box P3 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q9BZS1" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q9BZS1</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/50943" ref="ordinalpos=1&ncbi_uid=50943&link_uid=50943" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">FOXP3</span></a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">50943</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2" style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Cytokine inducible SH2-containing protein [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/O15524" style="text-decoration: none; background-color: rgb(255, 255, 255);">O15524</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/1154" ref="ordinalpos=1&ncbi_uid=1154&link_uid=1154" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">CISH</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2">NCBI Gene ID: 1154</font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><br/></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2">For Survival Signaling 2008 and 2011:</font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2"></font><div>SOCS1 suppressor of cytokine signaling 1</div><div>UniProt AccessionID: <a href="http://www.uniprot.org/uniprot/O15524" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: verdana, arial; font-size: 13px; line-height: 20.0819721221924px; background-color: rgb(255, 255, 255);">O15524</a></div><div><br/></div><font face="Georgia" size="2"></font><div>SOCS2 suppressor of cytokine signaling 2</div><div>UniProt AccessionID: <a href="http://www.uniprot.org/uniprot/O14508" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: verdana, arial; font-size: 13px; line-height: 20.0819721221924px; background-color: rgb(255, 255, 255);">O14508</a></div><font face="Georgia" size="2"></font><div><br/></div><div>SOCS3 suppressor of cytokine signaling 3</div><div>UniProt AccessionID: <a href="http://www.uniprot.org/uniprot/O14543" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: verdana, arial; font-size: 13px; line-height: 20.0819721221924px; background-color: rgb(255, 255, 255);">O14543</a></div><div><br/></div><div>For more info:</div><div>http://www.ncbi.nlm.nih.gov/mesh/68050826</div></div>

2015-11-15T18:45:56Z

<div><font face="Georgia" size="2">signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P40763">P40763</a></font></div><div><font face="Georgia" size="2">Gene Name: STAT3</font></div><div><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">6774</span></font></div><div><font face="Georgia" size="2"><br/></font></div><div><div><font face="Georgia" size="2">signal transducer and activator of transcription 1, 91kDa (STAT1)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P42224" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42224</a></font></div></div><div><font face="Georgia" size="2"><br/></font></div><div><div><font face="Georgia" size="2">signal transducer and activator of transcription 5A (STAT5A)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P42229" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42229</a></font></div></div><div><font face="Georgia" size="2"><br/></font></div><div><div><font face="Georgia" size="2">signal transducer and activator of transcription 5B (STAT5B)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P51692" style="text-decoration: none; background-color: rgb(255, 255, 255);">P51692</a></font></div></div>

2017-08-12T20:59:36Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">RAR-related orphan receptor C [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P51449" style="text-decoration: none; background-color: rgb(255, 255, 255);">P51449</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/6097" ref="ordinalpos=2&ncbi_uid=6097&link_uid=6097" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">RORC</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">6097</span></font></div>

2015-11-15T18:45:56Z

<table style="width: 723pt; border-collapse: collapse;" border="0" cellSpacing="0" cellPadding="0" width="964">\r\n <colgroup><col style="width: 723pt; mso-width-source: userset; mso-width-alt: 30848;" width="964">\r\n <tbody><tr style="height: 15pt;" height="20">\r\n\r\n <td style="border: 0px black; width: 723pt; height: 15pt; background-color: transparent;" class="xl65" height="20" width="964"><p><font size="3" face="Calibri">nuclear\r\n factor of activated T-cells, cytoplasmic, calcineurin-dependent</font></p><p><font size="3" face="Calibri">(NFAT homolog)</font></p><p><font size="3" face="Calibri">Gene Name: NFAT</font></p><p><font size="3" face="Calibri">Gene ID: 32321</font></p><p> </p></td>\r\n\r\n </tr>\r\n</tbody></table>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 12 </span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">receptor</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">, beta 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P42701" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42701</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3594" ref="ordinalpos=6&ncbi_uid=3594&link_uid=3594" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL12RB1</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3594</font></span></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"><br/></font></span></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 12 </span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">receptor</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">, beta 2 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q99665" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q99665</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3595" ref="ordinalpos=10&ncbi_uid=3595&link_uid=3595" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL12RB2</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBi Gene ID: 3595</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Zinc finger and BTB domain containing 7B [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/O15156" style="text-decoration: none; background-color: rgb(255, 255, 255);">O15156</a></font></div><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/51043" ref="ordinalpos=2&ncbi_uid=51043&link_uid=51043" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">ZBTB7B</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">51043</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin-1 receptor-associated kinase 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P51617" style="text-decoration: none; background-color: rgb(255, 255, 255);">P51617</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3654" ref="ordinalpos=1&ncbi_uid=3654&link_uid=3654" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IRAK1</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3654</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 7 receptor [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P16871" style="text-decoration: none; background-color: rgb(255, 255, 255);">P16871</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3575" ref="ordinalpos=4&ncbi_uid=3575&link_uid=3575" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL7R</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3575</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 23</span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">receptor</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q5VWK5" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q5VWK5</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/149233" ref="ordinalpos=3&ncbi_uid=149233&link_uid=149233" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL23R</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">149233</span></font></div>

2015-11-15T18:45:56Z

<div><span style="font-size: 13.3333330154419px;">Signal transducer and activator of transcription 5</span></div><div><div style="font-size: 13.3333330154419px;">Gene Name: STAT5</div><div style="font-size: 13.3333330154419px;">Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">100135887</span></div></div><font face="Georgia" size="2"></font><div><font face="Georgia" size="2"><br/></font></div>The term "stat5" is typically inclusive of the two highly related, structurally and functionally, transcription factors [1]:<div><font face="Georgia" size="2">Stat5A</font></div><div><font face="Georgia" size="2">UniProt ID: <span style="background-color: rgb(255, 255, 255);">P42229</span></font></div><div><font face="Georgia" size="2">Gene Name: STAT5A</font></div><div><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">6776</span></font></div><div><font face="Georgia" size="2">Stat5B</font></div><div><font face="Georgia" size="2">UniProt ID: <span style="background-color: rgb(255, 255, 255);">P51692</span><span style="background-color: rgb(255, 255, 255);"> </span></font></div><div><font face="Georgia" size="2">Gene Name: STAT5B</font></div><div><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">6777</span></font></div><div><br/></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interferon (alpha, beta and omega) receptor 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P17181" style="text-decoration: none; background-color: rgb(255, 255, 255);">P17181</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3454" ref="ordinalpos=2&ncbi_uid=3454&link_uid=3454" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IFNAR1</a><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;"> </span></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">3454</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 18</span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">receptor</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo </span>sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span><br/></font><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q13478" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q13478</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/8809" ref="ordinalpos=5&ncbi_uid=8809&link_uid=8809" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL18R1</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene Name: 8809</font></span></div><div style="font-size: 10pt; font-family: Arial, Verdana;"><font face="arial, helvetica, clean, sans-serif"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><br/></span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 10 </span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"></span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">receptor</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">, alpha [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P14778" style="text-decoration: none; background-color: rgb(255, 255, 255);">P14778</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3587" ref="ordinalpos=2&ncbi_uid=3587&link_uid=3587" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL10RA</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3587</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 17A [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q16552" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q16552</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3605" ref="ordinalpos=2&ncbi_uid=3605&link_uid=3605" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL17A</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3605</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span><br/></font><div style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2">Uniprot AccessionID: <a href="http://www.uniprot.org/uniprot/P10144" style="text-decoration: none; background-color: rgb(255, 255, 255);">P10144</a></font></div><div style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/3002" ref="ordinalpos=1&ncbi_uid=3002&link_uid=3002" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">GZMB</span></a></font></div><div style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2">NCBI Gene ID: 3002</font></div>

2015-11-15T18:45:56Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">T-cell surface glycoprotein CD4</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P01730" style="text-decoration: none; background-color: rgb(255, 255, 255);">P01730</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/920" ref="ordinalpos=1&ncbi_uid=920&link_uid=920" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CD4</span></a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: 920</font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Interleukin 6</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"> (interferon, beta 2) [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P05231" style="text-decoration: none; background-color: rgb(255, 255, 255);">P05231</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3569" ref="ordinalpos=2&ncbi_uid=3569&link_uid=3569" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL6</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 17.77777862548828px;">3569</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interferon, gamma [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span><br/></font><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P01579" style="text-decoration: none; background-color: rgb(255, 255, 255);">P01579</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/3458" ref="ordinalpos=2&ncbi_uid=3458&link_uid=3458" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">IFNG</span></a></font></div><div><font size="2" face="Georgia">NCBI Gene ID: 3458</font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Transforming growth factor, beta 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P01137" style="text-decoration: none; background-color: rgb(255, 255, 255);">P01137</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/7040" ref="ordinalpos=2&ncbi_uid=7040&link_uid=7040" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">TGFB1</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 7040</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2" style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">CD8a molecule [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P01732" style="text-decoration: none; background-color: rgb(255, 255, 255);">P01732</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/925" ref="ordinalpos=1&ncbi_uid=925&link_uid=925" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">CD8A</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 925</font></span></div><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><br/></div><div style="font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><br/></div><div><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">CD8+ Cytotoxic T Cells</span></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);"><br/></span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Runt-related transcription factor 3 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q13761" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q13761</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/864" ref="ordinalpos=1&ncbi_uid=864&link_uid=864" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">RUNX3</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 864</font></span></div>

2017-08-12T20:59:36Z

<div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">interferon gamma receptor </span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">1</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo sapiens</span></em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font></div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P15260" style="text-decoration: none; background-color: rgb(255, 255, 255);">P15260</a></font><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/3459" ref="ordinalpos=2&ncbi_uid=3459&link_uid=3459" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IFNGR1</a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: 3459</font></div><div><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interferon gamma receptor</span><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">2</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (interferon gamma transducer 1) [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo sapiens</span></em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span><br/></font><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P38484" style="text-decoration: none; background-color: rgb(255, 255, 255);">P38484</a></font></div></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/3460" ref="ordinalpos=9&ncbi_uid=3460&link_uid=3460" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IFNGR2</a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: 3460</font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 4 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P05112" style="text-decoration: none; background-color: rgb(255, 255, 255);">P05112</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3565" ref="ordinalpos=2&ncbi_uid=3565&link_uid=3565" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">IL4</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3565</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 6 receptor [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P08887" style="text-decoration: none; background-color: rgb(255, 255, 255);">P08887</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3570" ref="ordinalpos=17&ncbi_uid=3570&link_uid=3570" style="color: rgb(100, 42, 143); line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL6R</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3570</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 10 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P22301" style="text-decoration: none; background-color: rgb(255, 255, 255);">P22301</a></font></div><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><span class="highlight" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><a href="http://www.ncbi.nlm.nih.gov/gene/3586" ref="ordinalpos=1&ncbi_uid=3586&link_uid=3586" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL10</a></span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;"> </span></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 16.19982147216797px;">3586</span></font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Perforin 1 (pore forming protein) [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P14222" style="text-decoration: none; background-color: rgb(255, 255, 255);">P14222</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5551" ref="ordinalpos=2&ncbi_uid=5551&link_uid=5551" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">PRF1</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 5551</font></span></div>

2015-11-15T18:45:56Z

<div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Interleukin 4 receptor [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font></div><div><font face="Georgia" size="2">UniProt ID: <a href="http://www.uniprot.org/uniprot/P24394" style="text-decoration: none; background-color: rgb(255, 255, 255);">P24394</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/3566" ref="ordinalpos=8&ncbi_uid=3566&link_uid=3566" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">IL4R</a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: 3566</font></div>

2015-11-15T18:45:56Z

<div><font face="Georgia" size="2"><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Janus</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> </span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">kinase</span><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> </span><span class="highlight" style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">1</span></font></div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P23458" style="text-decoration: none; background-color: rgb(255, 255, 255);">P23458</a></font><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/3716" ref="ordinalpos=2&ncbi_uid=3716&link_uid=3716" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">JAK1</a></font></div><div><font face="Georgia" size="2">Gene ID: 3716</font></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Janus kinase 3 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P52333" style="text-decoration: none; background-color: rgb(255, 255, 255);">P52333</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3718" ref="ordinalpos=1&ncbi_uid=3718&link_uid=3718" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">JAK3</span></a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 3718</font></span></div>

2015-11-15T18:45:56Z

<font face="Georgia" size="2"><span class="highlight" style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Notch</span><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"> 1 [</span><em style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P46531" style="text-decoration: none; background-color: rgb(255, 255, 255);">P46531</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4851" ref="ordinalpos=8&ncbi_uid=4851&link_uid=4851" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">NOTCH1</a></font></div><div><span style="line-height: 17.999801635742188px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">NCBI Gene ID: 4851</font></span></div><br><br>null

2015-11-15T18:45:56Z

Tbet positively regulates itself [1, 7, 8]. STAT1 negatively regulates Tbet [1, 7, 8]. RORgt negatively regulates Tbet [1, 2, 3, 4, 5]. GATA3 negatively regulates Tbet [1, 2, 3, 4, 5]. Foxp3 negatively regulates Tbet [1, 2, 3, 4, 5].

Tbet is downregulated by Foxp3 [1, 2, 3, 4, 5, 6]

Tbet is upregulated by itself [1, 7, 8]

GATA3 is downregulated by Foxp3 [1, 2, 3, 4, 5, 6]

ROR-gt is downregulated by Foxp3 [1, 2, 3, 4, 5, 6]

Tbet is upregulated by STAT1 [1, 7, 8]

S_16 1 S_21 1 S_18 1 S_3 1 S_1 1 S_21 1 S_18 1 S_3 1

IL12R positively regulates STAT4 [1, 2]. GATA3 negatively regulates STAT4 [1, 3].

The negative influence from the IL-4 pathway on the IFN-g pathway is mediated by GATA-3 via STAT-4 [1, 3]

IL-12R signaling is mediated by STAT4 [1, 2]

S_24 1 S_3 1

GATA3 is negatively regulated by Foxp3, RORgt, and Tbet [1, 2, 3, 4, 5, 6]. GATA3 is positively regulated by itself and STAT6 [1, 7, 8, 9].

Foxp3 negatively regulates GATA3 [1, 2, 3, 4, 5, 6]

Tbet negatively regulates GATA3 [1, 2, 3, 4, 5, 6]

GATA3 positively self-regulates [1, 7, 8, 9]

RORgt negatively regulates GATA3 [1, 2, 3, 4, 5, 6]

STAT6 positively regulates GATA3 [1, 7, 8, 9]

S_17 1 S_21 1 S_18 1 S_1 1 S_3 1 S_21 1 S_18 1 S_1 1

Eomes is independently positively regulated by IL27R, Runx3, or Tbet [1, 2, 3, 4, 5].

Tbet contributes to the normal upregulation of Eomes [1, 2]

Eomes is positively regulates by IL-27, via its receptor IL-27R [1, 4, 5]

Eomes is positively regulated by Runx3 [1, 3]

S_9 1 S_41 1 S_1 1 S_41 1

IL2 positively regulates IL2R [1, 2, 3].

IL-2 binds to its receptor IL-2R [1, 2, 3]

S_12 1

TGFBR positively regulates SMAD2 [1, 2, 3].

SMAD2 is activated by the TGF-BR [1, 2, 3]

S_11 1

IL27 positively regulates IL27R [1, 2, 3].

IL-27 binds to its receptor IL-27R [1, 2, 3]

S_15 1

TGFB activates TGFBR [1, 2].

TGF-B binds to its receptor TGF-BR [1, 2]

S_39 1

IFNBR, IL27R, and JAK1 independently positively regulates STAT1 [1, 2, 3, 4, 5].

JAK1 activates STAT1 [1, 2, 3]

The signaling of IL-27R passes through STAT1 [1, 4, 5]

The signaling of IFN-BR passes through STAT1 [1, 4, 5]

S_30 1 S_9 1 S_48 1

IL4R positively regulates STAT6 [1, 2].

IL-4R acts through STAT6 [1, 2]

S_47 1

Foxp3 is negatively regulated by GATa3, RORgt, STAT3, and Tbet [1, 2, 3, 4, 5]. Foxp3 is positively regulated by SMAD2 and Foxp3 itself [1, 6, 7, 8].

STAT3 negatively regulates FOXP3 [1, 2, 3, 4, 5]

SMAD2 positively regulates Foxp3 [1, 6, 7, 8]

Foxp3 positively regulates itself [1, 6, 7, 8]

Tbet negatively regulates FOXP3 [1, 2, 3, 4, 5]

GATA3 negatively regulates FOXP3 [1, 2, 3, 4, 5]

RORgt negatively regulates FOXP3 [1, 2, 3, 4, 5]

S_18 1 S_20 1 S_21 1 S_1 1 S_3 1 S_8 1 S_20 1 S_21 1 S_1 1 S_3 1

STAT1 and Tbet both positively and independently regulate SOCS [1, 2, 3, 4]

SOCS1 is highly expressed in cells that express Tbet [1, 4]

The IFN-g signaling on SOCS1 is STAT1-dependent [1, 2, 3]

S_16 1 S_1 1

IL10R positively regulates STAT3 [1, 2, 3]. IL23R positively regulates STAT3 [1, 2, 3]. JAK3 positively regulates STAT3 [1, 4].

IL-10R signals through STAT3 [1, 2, 3].

IL-6R signaling, via JAK3, passes through STAT3 [1, 4]

IL-23R signals through STAT3 [1, 2, 3].

S_32 1 S_49 1 S_28 1

Foxp3, GATA3, Tbet independently negatively regulate RORGT [1, 2, 3, 4, 5]. SMAD2, STAT3, and RORgt itself all independently positively regulates RORGT [1, 6, 7, 8].

RORgt is upregulated by STAT3 [1, 6, 7, 8]

RORgt is upregulated by SMAD2 [1, 6, 7, 8]

RORgt is downregulated by Foxp3 [1, 2, 3, 4, 5]

RORgt is downregulated by Tbet [1, 2, 3, 4, 5]

RORgt is downregulated by GATA3 [1, 2, 3, 4, 5]

RORgt is upregulated by RORgt itself [1, 6, 7, 8]

S_8 1 S_20 1 S_21 1 S_1 1 S_18 1 S_3 1

TCR positively regulates NFAT [1, 2].

NFAT is activated by TCR [1, 2]

S_4 1

Il12 positively regulates IL12R [1, 2]. STAT6 negatively regulates IL12R [1, 3].

IL-12 binds to its receptor IL-12R [1, 2]

IL-12R is inhibited by the IL-4 pathway via STAT6 [1, 3]

S_13 1 S_17 1

ThPOK positively regulates itself [1, 7]. CD4 positively regulates ThPOK [1, 6]. GATA3 positively regulates ThPOK [1, 2, 3]. TCR positively regulates ThPOK [1, 4]. Tbet, Foxp3, and RORgt all independently and positively regulate ThPOK [1]. Runx3 negatively regulates ThPOK [1, 5]. CD8 negatively regulates ThPOK [1, 6].

ThPOK is more stable when CD4 is expressed [1, 6]

ThPOK regulates itself [1, 7]

ThPOK is a target of TCR [1, 4]

REF [1] predicts a positive regulation from Foxp3 to ThPOK 

REF [1] predicts a positive regulation from Tbet to ThPOK 

ThPOK is positively regulated directly by GATA3 [1, 2, 3]

REF [1] predicts a positive regulation from RORgt to ThPOK 

ThPOK is inhibited by Runx3 [1, 5]

ThPOK is more unstable when CD8 is expressed [1, 6]

S_21 1 S_1 1 S_41 1 S_25 1 S_36 1 S_40 1 S_3 1 S_4 1 S_18 1

IL18R positively regulates IRAK [1, 2].

IL-18R acts through IRAK [1, 2]

S_31 1

IL7 positively regulates IL7R [1, 2]. TCR negatively regulates IL7R [1, 3, 4].

A strong TCR stimulation downregulates IL-7R [1, 3, 4]

IL-7 binds to its receptor IL-7R [1, 2]

S_5 1 S_4 1

IL23 positively regulates IL23R [1, 2, 3].

IL-23 binds to its receptor IL-23R [1, 2, 3]

S_14 1

IL2R and IL7R independently activate STAT5 [1, 2, 3, 4, 5]. SOCS negatively regulates STAT5 [1, 2, 6].

IL-7R activates STAT5 [1, 2, 3, 4, 5]

SOCS is able to inhibit STAT5 [1, 2, 6]

IL-2R activates STAT5 [1, 2, 3, 4, 5]

S_7 1 S_19 1 S_27 1 S_19 1

IFN-B positively regulates IFN-BR [1, 2].

IFN-B binds to its receptor IFN-BR [1, 2].

S_35 1

IL18 positively regulates IL18R [1, 2]. STAT6 negatively regulates IL18R [1, 3].

IL-18 binds to its receptor IL-18R [1, 2]

IL-4 is able to block IL-18R signaling in a STAT6 dependent manner [1, 3]

S_10 1 S_17 1

IL10 positively regulates Il10R [1, 2].

IL-10 binds to its receptor IL-10R [1, 2]

S_45 1

RORgt positively regulates IL17 [1, 2].

ROR-gt is necessary for IL-17 expression [1, 2]

S_21 1

Eomes positively regulates GZMB [1, 2].

Eomes directly regulates the expression of Gzmb [1, 2]

S_6 1

Cd4 is positively regulated by Notch1 [1,6,7]. Cd4 is positively regulates by ThPOK [1,6,7]. Cd4 positively regulates itself [1,2,3]. Runx3 negatively regulates cd4 [1,4,5].

<div><span style="font-size: 10pt;">The CD4 self-activation </span><span style="font-size: 10pt;">represents the chromatin remodeling of the CD4 locus [1,2,3]</span></div>

Runx3 downregulates it [1,4,5]

CD4 is upregulated by Notch1 and ThPOK [1,6,7]

<div>CD4 is upregulated by Notch1 and ThPOK [1,6,7]</div>

S_36 1 S_41 1 S_25 1 S_50 1

RORgt positively regulates il6 [1, 2].

ROR-gt has a positive influence on IL-6 expression [1, 2]

S_21 1

Eomes, IRAK, STAT4, and Tbet all independently positively regulates IFNG [1, 2, 3, 4, 5, 6, 7]. STAT3 negatively regulates IFNG [1, 8].

STAT3 downregulates IFNg [1, 8]

IFNg is upregulated by Eomes [1, 2, 3, 4, 5, 6, 7]

IFNg is upregulated by STAT4 [1, 2, 3, 4, 5, 6, 7]

IFNg is upregulated by Tbet [1, 2, 3, 4, 5, 6, 7]

IFNg is upregulated by IRAK [1, 2, 3, 4, 5, 6, 7]

S_26 1 S_20 1 S_6 1 S_20 1 S_2 1 S_20 1 S_1 1 S_20 1

Foxp3 positively regulates TGFB [1, 2].

<div>Foxp3 is necessary for the production of TGR-B [1, 2]</div>

S_18 1

TCR or thPOK positively regulates CD8 [1, 2, 3, 4]. CD8 positively self-regulates [1, 8, 9]. Notch1 or Runx3 negatively regulate CD8 [1, 5, 6, 7]. 

ThPOK inhibits CD8 [1,2]

TCR inhibits CD8 [1,3,4]

Runx3 is essential for development of CD4-CD8+ lineage by activating CD8 [1,5]

Notch1 acts as a positive regulator of CD8 [1,6,7]

"The CD8 self-activation represents the chromatin remodeling of the CD8 locus [1,8,9]

S_50 1 S_4 1 S_25 1 S_40 1 S_4 1 S_25 1 S_41 1 S_4 1 S_25 1

RUNX3 positively regulates itself [1]. CD8 and STAT5 independently positively regulates RUNX3 [1, 7, 8, 9]. CD4 or ThPOK inhibit RUNX3 [1, 2, 3, 4, 5, 6].

CD4 is an inhibitor of Runx3 (1, 2, 3, 4, 5, 6]

ThPOK is an inhibitor of Runx3 (1, 2, 3, 4, 5, 6]

STAT5 is an activator of Runx3 [1, 7, 8, 9]

The self regulation of Runx3 is predicted by REF 1.

CD8 is an activator of Runx3 [1, 7, 8, 9]

S_41 1 S_36 1 S_25 1 S_40 1 S_36 1 S_29 1

IFNG positively regulates IFNGR [1, 2, 3].

IFN-g binds to its receptor IFN-gR [1, 2, 3]

S_38 1

STAT1 negatively regulates IL4 [1, 3]. GATA3 positively regulates IL4 [1, 2].

GATA3 induces IL-4 [1, 2]

STAT-1 negatively regulates IL-4 expression [1, 3]

S_3 1 S_16 1

IL6 positively regulates IL64 [1, 2, 3].

IL-6 binds to its receptor IL-6R [1, 2, 3]

S_37 1

GATA3 positively regulates IL10 [1, 2].

GATA3 increases IL-10 production [1, 2]

S_3 1

Eomes positively regulates Prf1 [1, 2, 3].

Eomes directly regulates the expression of Prf1 [1, 2, 3]

S_6 1

SOCS1 negatively regulates IL4R [1, 4]. IL4 positively regulates IL4R [1, 2, 3].

IL-4 binds to its receptor IL-4R [1, 2, 3]

SOCS1 blocks the IL-4R pathway [1, 4]

S_43 1 S_19 1

IFNgr positively regulates JAK1 [1, 2, 3].

The signaling of IFN-gR requires JAK1 [1, 2, 3]

S_42 1

IL6R positively regulates JAK3 [1, 2].

IL-6R signaling cascade acts through JAK3 [1, 2]

S_44 1

Dll1 activates Notch1 [1, 2].

Dll1 binds to its receptor Notch1 [1, 2]

S_23 1